Cellular/Molecular SNAP-25 Is a Target of Protein Kinase C Phosphorylation Critical to NMDA Receptor Trafficking
نویسندگان
چکیده
C. Geoffrey Lau,1 Yukihiro Takayasu,1 Alma Rodenas-Ruano,1 Ana V. Paternain,2 Juan Lerma,2 Michael V. L. Bennett,1 and R. Suzanne Zukin1 1Rose F. Kennedy Center, Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, and 2Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas-Universidad Miguel Hernández, 03550 San Juan de Alicante, Spain
منابع مشابه
SNAP-25 is a target of protein kinase C phosphorylation critical to NMDA receptor trafficking.
Protein kinase C (PKC) enhances NMDA receptor (NMDAR)-mediated currents and promotes NMDAR delivery to the cell surface via SNARE-dependent exocytosis. Although the mechanisms of PKC potentiation are established, the molecular target of PKC is unclear. Here we show that synaptosomal-associated protein of 25 kDa (SNAP-25), a SNARE protein, is functionally relevant to PKC-dependent NMDAR insertio...
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